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Closing Practice Gaps in SM: Recognizing and Differentiating SM From Other Mast Cell Disorders

Video
This activity is available for 0.50 CME/CE credit(s).

Released: August 20, 2026

Expiration: August 19, 2027

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Early recognition and effective management of systemic mastocytosis (SM) require advanced practice providers to think beyond the skin, as systemic symptoms often present alongside cutaneous involvement. Learn how to better recognize SM in your practice by understanding its heterogeneous clinical presentations, how it differentiates from other mast cell disorders, and the diagnostic criteria that must be met to confirm a diagnosis.

Closing practice gaps in SM 1

Pre Assessment

Assess your current knowledge and clinical approach before beginning your video.
1.

How many people with systemic mastocytosis do you provide care for in a typical month?

2.

For those who practice in academic or community settings, please indicate your practice setting:

3.

A 36-yr-old man presents with progressively increasing reddish-brown macules on his trunk and extremities. Two years ago, the lesions were attributed to postinflammatory hyperpigmentation from acne, but they have continued to spread despite successful acne treatment.

Which additional clinical finding would most strongly support further evaluation for SM?

4.

A 45-year-old woman presents with recurrent episodes of unexplained anaphylaxis, flushing, and abdominal cramping. Her baseline serum tryptase is 28 ng/mL, and peripheral blood testing detects a KIT D816V mutation.

According to the WHO, which of the following is a major criterion to confirm the diagnosis of SM?